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Basic Information about Rybelsus

What is Rybelsus?

Rybelsus is a medicine that is used to control blood sugar, or glucose, levels. It is intended for use by adults with type 2 diabetes, which is difficult to control with diet and exercise. This drug can be used both as monotherapy (if for some reason metformin cannot be used) and in combination with other diabetic medications. Although the active ingredient in Rybelsus, semaglutide, helps reduce appetite and weight, it should still only be used in combination with a properly selected diet and exercise regimen.

How Is Rybelsus Used?

Rybelsus, which is manufactured by the Danish pharmaceutical company Novo Nordisk AS, is available to patients in the form of tablets with dosages of 3, 7 and 14 mg of the active substance semaglutide. This medicine can only be purchased with a doctor’s prescription. Typically, the starting dose of Rybelsus is 3 mg once daily. After about 1 month, the dosage is increased to 7 mg per day. If necessary, after another one to two months, the dosage can be increased to the maximum, which is 14 mg per day. A gradual increase in dosage is necessary for the body to adapt to the medicine, as well as to reduce the severity of side effects.

What Is the Mechanism of Action of Rybelsus?

When talking about how Rybelsus works, it is worth remembering that type 2 diabetes is a disease in which the body does not produce enough insulin to maintain the amount of glucose in the blood at the desired level, or when the body cannot effectively use stored insulin. This results in elevated blood glucose levels. Semaglutide, which is a GLP-1 receptor agonist, works in the same way as the natural GLP-1 hormone. The medicine increases the amount of insulin that the pancreas secretes in response to food consumed.

What Are the Advantages of Rybelsus?

The effectiveness of Rybelsus in controlling blood sugar levels in patients with type 2 diabetes has been proven in seven large clinical studies involving almost 6,000 people. The results of Rybelsus in reducing glycosylated hemoglobin are even better than those of such common diabetes control drugs as empagliflozin, sitagliptin or liraglutide. A positive side effect of Rybelsus therapy is a decrease in body weight, which is observed after 5-6 months of taking the drug. Clinical trial data also suggests that Rybelsus may reduce the incidence of heart attacks and strokes.
When considering the immunogenicity of Rybelsus, it should be taken into account that due to the potential immunogenic properties of protein and peptide drugs, antibodies to the drug may appear in some patients. Approximately 0.5% of patients demonstrate antibodies to Rybelsus after a sufficiently long period of treatment, but none of them have yet been found to have neutralizing antibodies to semaglutide to date.